ORLANDO HOME MOLD INSPECTIONS
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Orlando Mold Inspection, Mold has been link to many health issue! For more info go to www.epo.gov.

Mold Problem?

Why Mold Inspection? 
Asthma and Allergies!
Protect Your Family and Home!
Befor you buy make sure your Home is Safe!
Do you feel better when your away from your home?

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  • Commercial and Residential Mold Inspection
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  • All our sampling is by performed Major Lab Company!
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  • For More Toxic Mold Information, WWW.EPA.COM


Mold is in most Florida Home, due to high relative humidity in this region all year long, Mold gradually destroy the things they grow on, Mold purpose in life is to break thing down like leaves and tree. Most mold will grow in the interior and exterior surface in the AC unit, AC duct, Drywall, Furniture, Clothing, Carpet, Wood floor and Vinyl wall paper. To prevent damage to building materials and furnishings and avoid potential of Health Risks, by Controlling moisture and eliminating mold growth. Clean or Repair any water leak within 24-48 Hours, this are crucial time. What is the criteria for mold test? Read the EPA booklet and follow recommendation guideline or visit WWW.EPA.GOV.

Beware of Mold Company that will do the Mold test and do there own remediation, Conflict of Interest, A Unbiased Mold inspector is Highly Recommended.

  • Roof Leaks
  • Hard to find Moisture Intrusion!
  • Musty Smell?
  • Sewer waste flooding?
  • Plumbing leaks?

                                               


  Orlando Mold home inspections
GOT MOLD? HEALTH AND SAFETY ISSUE! PROTECT YOUR FAMILY AND INVESTMENT, CALL TODAY FOR YOUR PEACE OF MIND!
Less than Two Years Old AC Unit: Visible Mold Suspect, Mold has been link to Many Health Issue! for more information go to WW.EPA.GOV.

What are the Symptoms of Mold exposure!

The following is a list of the most common symptoms of fungal exposure. This is not an all inclusive list, there are other symptoms and if you feel that you are being exposed to some form of toxic mold, you should seek medical attention to determine your health risks. Keep in mind that people rarely experience all of the symptoms listed. Most people with some form of Mycotoxicosis will meet at least 8 (recent symptoms) of the following criteria:

Headaches
Respiratory distress, coughing, sneezing
Difficulty swallowing, choking, spitting up
Burning in the throat and lungs (often misdiagnosed as acid reflux)
Asthmatic signs; wheezing, shortness in breath, coughing, burning in lungs, etc.
Irritable bowel syndrome, nausea, diarrhea, sharp abdominal pains, stomach lesions
Bladder, liver, spleen, or kidney pain
Dark or painful urine
Dirt-like taste in mouth, coated tongue
Food allergies/leaky gut syndrome/altered immunity
Memory loss; brain fog, slurred speech, occasionally leading to dementia
Vision problems
Swollen lymph nodes
Large boils on neck (often a sign of anaphylaxis)
Yellowing of nails, ridges, or white marks under nail
Thyroid irregularities, sometimes leading to complete dysfunction; adrenal problems
Anxiety/depression, heart palpitations - confusion
Extreme blood pressure, cholesterol, or triglycerides irregularities
Ringing in ears, balance problems (very common), dizziness, loss of hearing
Chronic fatigue
Intermittent face flushing; almost always systemic, Called the Mylar Flush
Night head sweats, and drooling while sleeping, profuse sweating
Nose bleeds (stachybotrys)
Bruising/scarring easily; rash or hives, bloody lesions all over the skin
Reproductive system complications; infertility, changes in menstrual cycles, miscarriage
Sudden weight changes
Cancer
Hair loss, very brittle nails
Joint/muscle stiffness and pain
Irregular heart beat/heart attack
Seizures, inadvertent body jerking, twitching, inadvertent facial movements or numbness in face 

         
           Basic Mold Cleanup

The key to mold control is moisture control. It is important to dry water damaged areas and items within 24-48 hours to prevent mold growth. If mold is a problem in your home, clean up the mold and get rid of the excess water or moisture. Fix leaky plumbing or other sources of water. Wash mold off hard surfaces with detergent and water, and dry completely. Absorbent materials (such as ceiling tiles & carpet) that become moldy may have to be replaced.



   Ten Things You Should Know About Mold

  1. Potential health effects and symptoms associated with mold exposures include allergic reactions, asthma, and other respiratory complaints.  
  2. There is no practical way to eliminate all mold and mold spores in the indoor environment; the way to control indoor mold growth is to control moisture.
  3. If mold is a problem in your home or school, you must clean up the mold and eliminate sources of moisture.
  4. Fix the source of the water problem or leak to prevent mold growth.
  5. Reduce indoor humidity (to 30-60% ) to decrease mold growth by: venting bathrooms, dryers, and other moisture-generating sources to the outside; using air conditioners and de-humidifiers; increasing ventilation; and using exhaust fans whenever cooking, dishwashing, and cleaning.
  6. Clean and dry any damp or wet building materials and furnishings within 24-48 hours to prevent mold growth.
  7. Clean mold off hard surfaces with water and detergent, and dry completely. Absorbent materials such as ceiling tiles, that are moldy, may need to be replaced.
  8. Prevent condensation: Reduce the potential for condensation on cold surfaces (i.e., windows, piping, exterior walls, roof, or floors) by adding insulation.
  9. In areas where there is a perpetual moisture problem, do not install carpeting (i.e., by drinking fountains, by classroom sinks, or on concrete floors with leaks or frequent condensation).
  10. Molds can be found almost anywhere; they can grow on virtually any substance, providing moisture is present. There are molds that can grow on wood, paper, carpet, and foods. Why Toxic Mold Inspection?

Is your home making you sick? Is your children or pet always sick? Is your home have musty or moldy smell? Did you have a flood or leak in the home?

Only in the past decade or less have we begun to understand the potential health risks associated with exposure to toxic mold contamination.

Spores can be inhaled, absorbed through the skin or ingested on our food. And, because some people are more susceptible than others, one person may become debilitated by exposure to mold in the home, another person sharing the same environment is essentially unaffected. Infants, the elderly and anyone with immune system deficiencies due to disease, chemotherapy, etc. are particularly susceptible to serious illness following exposure to microbial contamination.

Many species of black mold and mildew (or the mycotoxins they produce) can cause or aggravate a number of ailments. Common effects from molds such as stachybotrys atra, penecillium, cladosporium and several strains of aspergillius, are asthma, pneumonitis, upper respiratory problems, sinusitis, dry cough, skin rashes, stomach upset, headaches, disorientation and bloody noses. Numerous other species of mold and mildew are also toxic, and many mycotoxins are known carcinogens. Severe exposures can lead to internal bleeding, kidney and liver failure and pulmonary emphysema. Such health risks due to the presence of mold in a dwelling are a serious concern to occupants, and can pose potential liability for owners of rental properties.

- Contamination of residential properties by toxic mold and mildew is becoming more and more prevalent. Although mankind has been aware for thousands of years that mold thrives in damp conditions, only recently have we begun to understand how dramatically its presence can impact us. Toxic mold and mildew is not discerning, affecting both old and new buildings.

The odor or appearance of mold can signal a variety of problems. The moisture that gives life to fungal growth in older buildings can be either a moisture problem created by tenant's use, or water intrusion due to leaky components, or both. In new construction, it could also indicate the existence of construction defects.

" I Don't Remember Mold Being a Concern Twenty Years Ago"

Molds and mildew are everywhere in our environment, and in nature, they perform the very important function of breaking down organic matter. These microbes need very little to survive and thrive: air, moisture (liquid water isn't necessary, most species propagate with only 40%-60% relative humidity), and food. Fungi are especially fond of building materials like sheetrock and wood, carpets, and enjoy soft goods such as furniture and clothes. Every home offers a smorgasbord for eager spores!

There are a number of reasons for the increasing problem of mold and mildew in our homes, not the least of which is the fact that Title 24 to the United States Code of Federal Regulations, relating to energy conservation, brought new construction methods and materials, meaning that buildings don't "breathe" as freely, trapping moisture vapors inside the building. Most newer homes are built on concrete slabs, which emit moisture for several years as they cure, and because they are porous, moisture from the soil beneath the slab also vaporizes into the living space. Leaky roofs, windows, and plumbing, whether caused by poor construction or lack of timely repairs, often result in colonization of mold and mildew spores. The microbial spores become airborne, spreading inside wall cavities, behind cabinets and wallpaper, and through ventilation systems. When moisture and temperature conditions are favorable, widespread contamination can occur in a surprisingly short time.

What's Next ?

The toxic mold environmental risk may be one of the next major real estate “due diligence” concerns, especially in property development areas where major flooding has occurred. The problem is that this not only includes known residential and commercial flood areas incidents, but also numerous minor water releases due to plumbing failures, conductive condensation, house water leaks and accidents. The toxic mold concern could also be a problem where fires occurred at residential properties.

The second major concern is that one might not be able to permanently eliminate the entire toxic mold from the structure. There also remains a great propensity for future reoccurrence. The health risk/hazard could be back again. Therefore, we must recommend that great care be exercised to remove and dispose of all products, which have been contaminated by the toxic mold contaminated. This recommendation is supported by the Department of Health Administrations in many states.

The third concern is that States’ Health Departments will consider ambiguous and genetic disposition as a response to the publics’ inquiries. There will be some people, especially children, that will exhibit more adverse reactions, including death, lung tissue damage, and memory loss, than other persons exposed to the toxic mold. This may depend on the chemical sensitivity, genetic disposition, predisposing health history (such as allergies, asthma, smoking, etc.). For some, the exposure to the toxic mold spores may just be a “health risk” and to others, it may be a real “health hazard” (potential life-threatening and loss of “quality of life”.) Whether a potential liability concern is a risk or hazard will be paramount in defining the critical level of due diligence and disclosure response by responsible parties. There are already several major lawsuits concerning toxic mold exposure in residential and commercial buildings throughout the United States. Currently, most health organizations consider exposure to Stachybotrys mold as a health hazard.

Also, keep in mind that most responses leading to testing, investigations, and abatement of the Stachybotrys toxic mold are due directly to occupant complaints or documented detrimental health effects. Stachybotrys mold may evolve to a point where it is regarded with the same cautions, response and liability concerns as those attributed to lead-base paint and asbestos. Health hazards and risks associated with concern to exposure to Stachybotrys are currently considered as short-term effects. Exposure to radon gas in houses is considered a long-term health risk and is not considered a short-term hazard.

Mold, what is it all about?

Mold has certainly made its way into people's homes as well as the headlines recently. Many people still don't fully understand the health hazards of fungal exposure. The term toxic mold is somewhat misleading as it exudes an idea that certain molds are toxic, when actually certain types of molds produce secondary metabolites that produce toxins. The correct term is mycotoxins. Airborne mycotoxins from can definitely destroy one's health. Sometimes, people are unaware that they are breathing mold spores and mycotoxins until they are very sick. Certain people have a minor allergic reactions to the non-toxic mold, but once you leave the affected area they most likely recover with few serious side effects. However, if they have been exposed to the dangerous molds such as Stachybotrys or Chaetomium, they could suffer from a myriad of serious symptoms and illnesses such as chronic bronchitis, learning disabilities, mental deficiencies, heart problems, cancer, multiple sclerosis, chronic fatigue, lupus, fibromyalgia, rheumatoid arthritis, multiple chemical sensitivity, bleeding lungs and much more.

Unfortunately, the government has failed to establish guidelines that determine unhealthful amounts of poor indoor air quality standards, making it impossible for thousands of sick people to obtain help during this looming national health crisis. This is the main reason why so many people are confused about the damage mold can cause. As most know, many molds can cause allergens that can affect some of the population, but some molds can also cause toxins, which can affect everyone, depending on the length of exposure. Approximately 25 million Americans suffer from allergic reactions to molds yet most of them don't even realize that when they're sneezing and sniffling the cause could be from fungi.

The molds that produce airborne toxins that can cause serious symptoms, such as breathing difficulties, memory and hearing loss, dizziness, flu-like symptoms, and acid reflux. Common ailments from toxigenic mold---including allergies (hypersensitivity after initial toxicity), and excessive bruising---usually can be treated and reduced after people leave their contaminated environment. Often medication, diet, and other treatment protocols are necessary. But other health problems may remain permanently, such as brain damage and weakened immune systems. Eyesight, memory, coordination/balance, and hearing are generally the most common residual effects that often do not improve after treatment in most cases.

Molds can be found wherever there is moisture, oxygen, and something to feed on. In the fall, they grow on rotting logs and fallen leaves, especially in moist, shady areas. In gardens, they can be found in compost piles and on certain grasses and weeds. Molds grow in our homes in moist warm areas like damp basements, closets, and bathrooms, even after the moisture has dried up. Also, molds can grow in places where fresh food is stored, refrigerator drip trays, house plants, humidifiers, garbage pails, mattresses, upholstered furniture, or foam rubber pillows. The worst place that molds can grow, however, is inside wall cavities and flooring of our homes, wherever there may be cellulose materials they can feed on, such as wood, ceiling tiles, or plasterboard, even if they are not visible, and they have sustained water damage at one time or another. This is very common if there has been a plumbing leak or an inadequate roof. Actually, any type of water damage can cause a mold problem.

Many people are either unaware, ignorant, or in denial about the severe health hazards involved with some types of indoor household molds. Molds come in thousands of different varieties, but a few who are some of the offenders that invade our homes. Alternaria and Cladosporium are the molds most commonly found both indoors and outdoors throughout the United States. Aspergillus, Penicillium, Helminthosporium, Epicoccum, Fusarium, Mucor, Rhizopus, and Aureobasidium are also common. One of the mycotoxins, aflatoxin, is produced by the fungi Penicillium, Aspergillus flavus and Aspergillus parasiticus. Four different aflatoxins, B1, B2, G1 and G2, have been identified with B1 being the most toxic, carcinogenic and prevalent. Another very dangerous family of toxin producers is Fusarium. The toxins zearalenone, trichothecenes or moniliformin can be formed by various types of Fusarium including F. moniliforme, F. oxysporum, F. culmorum, F. avenaceum, F. equiseti, F. roseum, and F. nivale.

The most dangerous mold strains are: Chaetomium (pronounced Kay-toe-MEE-yum) and Stachybotrys chartarum (pronounced Stack-ee-BOT-ris Shar-TAR-um) as they have been proven to produce demylenating mycotoxins among others, meaning they can lead to autoimmune disease. Under certain growth and environmental conditions, both of these fungi release toxic, microscopic spores and several types of mycotoxins that can cause the worst symptoms which are usually irreversible such as neurological and immunological damage. Some of these natural mycotoxins include a very strong class known as trichothecenes. Trichothecenes are also produced by several common molds including species in the genera Acremonium, Cylindrocarpon, Dendrodochium, Myrothecium, Trichoderma, and Trichothecium. The trichothecenes are potent inhibitors of DNA, RNA, and protein synthesis, and have been well studied in animal models because of concern about their potential misuse as agents of biological warfare, due to their ability to destroy human health (mentally and physically), and never appear in an autopsy.

The disturbing factor about airborne mycotoxins is that it is impossible to know how much damage they have caused to one's health until it is too late. Therefore, It is imperative to not knowingly expose oneself even for brief periods of time in any place that smells moldy or has an appearance of mold or mildew. If you suspect that the air quality in your home is being compromised by mold spores you can have the air tested, but it can be quite expensive in some instances. It's worth it if it helps save your health. Mold Help approved testing companies are listed on this site with more reasonable costs. These testing companies have been approved due to their thoroughness, value, and efficacy. You will find that their cost is generally lower than most, but this in no way compromises the value of their work.

Some molds are cryophytes (these adapt to low temperatures), some are thermo tolerant (they adapt to a wide range of temperatures) and some are thermophiles (they adapt to high temperatures). Depending on the species, these microbes will grow just about anywhere. Not even a fire in excess of 500 degrees Fahrenheit has been able to destroy some molds such as Stachybotrys. Mold requires a compatible temperature for each species. Environmental factors (temperature, nitrogen, oxygen, etc. ) are necessary compounds for indoor molds to thrive.

Mold also needs an organic source of food. People might be confused as mold can grow on glass, tile, stainless steel, cookware, etc., but it is generally feeding off of some organic source deposited on this material (oils, film, dirt, skin cells, etc.). The fiberglass insulation which some assume that mold does not grow on their product which is a fairly true statement, however, it grows on the organic debris that become trapped in these products. Mold also grows on things such as wood, fabric, leather, gypsum, fiberboard, drywall, stucco, and many insulation fibrous materials. All molds require some form of moisture to grow however, like temperature, the amount of moisture varies for different species. Some are xerophillic (colonize under very dry conditions) some are xerotolerant (colonize under a wide range of moisture levels) and some are hydrophilic (colonize at high moisture levels). It does not have to be a leak. . . Humidity or moisture content of the substrate can often be sufficient (relative humidity 50% start becoming problematic in many indoor cases). It can spread very easily through any HVAC system.

Mycotoxins are examples of chemical substances that molds create generally as secondary metabolites, thought to possibly play a role in either helping to prepare the substrate on which they exist for digestion, as defense mechanisms, and some have suggested that they may be produced when the organisms are under stress, which could be related to competition/defense, or simply due to inhospitable environmental conditions. The mycotoxins, which are also neurotoxins (a toxin that is determined to cause neurological damage), most commonly reach people from the air, via spores from the molds in question. They are also found in small particulates at times which may often represent mold dust, small particles of mold that has dried and turned to dust. Spores, when inhaled, can begin to colonize in the sinuses and throughout the body, including the brain, lung and gut after a period of time.

Sick buildings are one of the major causes of fungal illness, primarily mycotoxicosis, in industrialized nations today. The United States is the least developed in fungal illness research and assistament to the community due to the high costs and fear of reprisals, so sadly, most American physicians have little or no education in treating this health crisis. The average American physician knows only how to identify a mold hyphae under a microscope, at best. Mycotoxicosis, often mistakenly called "Toxic Mold Syndrome" out of ignorance, has reached epidemic proportions at a national level in the United States due to defective construction, lack of regular maintenance, shoddy and inappropriate building materials, ignorance, and lack of government involvement; all or in part due to the high costs of standard and substandard remediation.

This illness has been so misunderstood, some who profit from the misfortunes of these poor individuals even go so low as to claim that there is no evidence to back up the fact that mold can cause permanent neurological, psychological, immunological and pathological damage, despite the medical data from well respected physicians all over the world


 

Suit: Mold killed 3 kids

TAMPA - The families of three pediatric-cancer patients sued a Florida hospital this week, claiming their children died after contracting fungal infections from renovations at the facility.

The lawsuit filed Tuesday by parents against St. Joseph's Hospital Inc. in Tampa claims the children were exposed to pathogenic fungi because the hospital failed to properly seal off an area under renovation.

Each of the children -- ages 2, 5, and 9 -- had been previously diagnosed with acute lymphoblastic leukemia, a cancer of white blood cells. Two had gone into remission, and a third was battling the disease.

Attorney Steven Yerrid, who represents the families, said they think dust containing the fungus became airborne and invaded the patients' rooms, "where all these children then were forced to engage in yet another battle."

In a statement, the hospital said patient safety is its top priority, and that it takes necessary measures to reduce infections. Those include using barriers around construction areas, filtering the air and monitoring ventilation systems.

All those measures were in place when the infections occurred, spokeswoman Lisa Patterson said. The hospital is part of the BayCare Health System, a network of not-for-profit hospitals in the region.

"Cancer kills more children than any other disease," the statement read. "Sometimes, despite all the measures we have in place, all the medical expertise we provide, and all the personal care we deliver, patients do not survive."

The lawsuit offers these patient accounts:

Matthew J. Gliddon, 5, was first diagnosed with leukemia in 2005. After being treated with chemotherapy, he went into remission. But 2 1/2 years later, his cancer returned. From November 2007 to February 2008, he spent most of his time as a patient at St. Joseph's Hospital receiving treatment.

Matthew's white blood count dropped very low, and he was at risk for bacterial and fungal infections.

According to the lawsuit, physicians discovered a spot on his nose, which grew and began destroying tissue. A biopsy later determined he was suffering from a nasal mold infection. As a result, Matthew underwent surgery that removed most of his septum. Still suffering from cancer, and now in the presence of a mold infection, he was not a candidate for a bone-marrow transplant. Matthew died in April.

Around that time, Kaylie Gunn-Rimes, 2, was taken to St. Joseph's.

She had been diagnosed with leukemia when she was less than a year old. Last January, the toddler had an allergic reaction to one of her medications and was admitted to the hospital. Though she was cancer-free at the time, she was staying on the pediatric-cancer floor and developed a fungal infection in her lungs. She spent 76 days on a ventilator before dying.

The third patient was Sierra Kesler, 9. Her leukemia had been in remission, but in March 2008 she went to the hospital and physicians discovered it had returned. She was given chemotherapy and went into remission again. The lawsuit says Sierra returned to the hospital a week later with a fever and coughing. She eventually had to be intubated and died in May.

In each case, tests confirmed the presence of a pathogenic fungi.

The lawsuit says patient rooms were right above the construction, where renovation work would have created a moderate to high level of dust. The air-conditioning systems would have brought air from the outside into patient rooms, it claims.

Sometimes, the patients had to be transported through the construction area. The parents claim the hospital failed to take precautions, including sealing the area under construction.



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MOLD TERMINALOGY 


Absidia sp. – Allergenic. A zygomycete fungus which is considered common to the indoor environment. May cause mucormycosis in immune compromised individuals. The sites of infection are the lung, nasal sinus, brain, eye, and skin. Infection may have multiple sites. Absidia conidia have been an invasive infection agent in AIDS and neutropenic patients, as well as, agents of bovine mycotic abortions, and feline subcutaneous abscesses.


Acremonium sp.
(Cephalosporium sp.) – Allergenic and toxic. Can produce a trichothecene toxin, which is toxic if ingested. It was the primary fungus identified in at least two houses where the occupant complaints were nausea, vomiting, and diarrhea. It can produce mycetomas, infections of the nails, onychomycosis, corneal ulcers, eumycotic mycetoma, endophthalmitis, meningitis, and endocarditis.


Alternaria sp.
– Allergenic. Commonly found in outdoor air, on many kinds of plants and food products and prefers rotting farmland manure. It may be resistant to fungicides. Alternaria is considered an occasional contaminant of water damaged building materials which contain cellulose. Although Alternaria is a notable source of fungal allergy, pathogenic infections are also reported infrequently.


Arthrographis spp.
– Should be considered allergenic. A species of Arthrographis, A. kalrae, has been documented in onychomycosis and has been recovered from the skin, nails, and respiratory sites but has not been established as an etiological agent. No toxic related diseases are of record to date.


Aspergillus sp.
– Allergenic, pathogenic, and toxic. A genus of fungi containing approximately 150 recognized species. All of the species contained in this genus should be considered allergenic. Various Aspergillus species are a common cause of extrinsic asthma (immediate-type hypersensitivity: type I). Acute symptoms include edema and bronchospasms. Chronic cases may develop pulmonary emphysema. Members of this genus are reported to cause a variety of opportunistic infections of the ears and eyes. Severe pulmonary infections may also occur. Many species produce mycotoxins, which may be associated with disease in humans and other animals. Toxin production is dependent on the species or a strain within a species and on the food source for the fungus. Some of these toxins have been found to be carcinogenic in animal species. Several toxins are considered potential human carcinogens.


Aspergillus clavatus
– Allergenic. This distinctive species is a common soil fungus with widespread distribution in soils in warmer climates. Not common in indoor environments, but is quite widely distributed in some kinds of foods, especially cereals, and it has been frequently associated with the brewing industry. No toxic or invasive diseases have been documented to date.


Aspergillus flavus
– Allergenic, pathogenic, and toxic. This species may be recovered from the indoor environment; it has been reported in water damaged carpets. Its presence has been associated with reports of asthma. Approximately 50% of the strains are capable of producing a group of mycotoxins - in the aflatoxin group. Aflatoxins are known animal carcinogens. There is limited evidence to suggest that this toxin is also a human carcinogen. The production of the fungal toxin is dependent on the growth conditions and on the substrate used as a food source. The toxin is poisonous to humans by ingestion and may directly affect the liver. Experiments have indicated that it is teratogenic and mutagenic. This fungus may also result in disease via inhalation and is associated with aspergillosis of the lungs and/or disseminated aspergillosis. This fungus is occasionally identified as the cause of corneal, otomycotic, and infections in the nasal cavity.


Aspergillus fumigatus
– Allergenic and pathogenic. This species may be recovered from the indoor environment. Considered as a principle cause for both invasive and allergic aspergillosis. This organism will particularly affect individuals who are immune compromised. It is considered a true human pathogen. No toxic diseases have been documented to date.


Aspergillus glaucus
– Allergenic and pathogenic. This species may be recovered from the indoor environment. It has been reported as a common outdoor fungus in the winter. This species is only occasionally pathogenic and has been associated with sinusitis, otitis, cerebral, orofacial, and pulmonary infections. No toxic diseases have been documented to date.


Aspergillus nidulans
– Allergenic and toxic. This species is not considered common to indoor environments. This species has been reported in a variety of animal and human infections including invasive and systemic disease including aspergillosis of the lungs and/or disseminated aspergillosis. It can produce the mycotoxin sterigmatocysti that has been shown to produce liver and kidney damage in lab animals. 


Aspergillus niger
– Allergenic. This species is considered common to indoor environments. It is common in secondary organisms following bacterial otitis and is more commonly being implicated in pulmonary disease in immune compromised hosts. It has also been reported to cause skin infections.


Aspergillus terreus
– Toxic. Found in patients with cystic fibrosis, this species has grown in the human ear causing otomycosis and can damage human nails (onychomycosis) and skin. It can produce a variety of mycotoxins, including itaconic acid, patulin, mevinolin, and citrinin, which may be associated with disease in humans and animals.


Aureobasidium sp.
– Allergenic. This species has been associated with dermatitis, peritonitis, pulmonary infection, and invasive disease in AIDS patients. Probably acquired by traumatic implantation. May be recovered as a contaminant from human cutaneous sites. No toxic diseases have been documented to date. Commonly considered a contaminant.

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B
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Beauveria – Allergenic. Not considered to be common to indoor environments. Reported to cause mycotic keratitis and occasional pulmonary infections. No toxic diseases have been documented to date.


Bipolaris sp.
– Toxic. Common to both indoor and outdoor environments. Older obsolete names include Drechslera and Helminthosporium. This fungus produces large spores, which would be expected to be deposited in the upper respiratory tract. Various species of this fungus can produce the mycotoxin—sterigmatocystin—that has been shown to produce liver and kidney damage when ingested by laboratory animals.


Botrytis sp.
– Allergenic. No toxic or invasive diseases have been documented to date. Commonly considered a contaminant.

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C
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Cephalosporium sp.
– See Acremonium sp.


Chaetomium sp.
– Commonly considered a contaminant, but are also encountered as causative agents of infections in humans.


Chrysosporium spp.
– Common outdoor mold. Rare agents of onychomycosis, skin lesions, endocarditis, and uncommon agents of the pulmonary mycosis adiaspiromycosis. No toxic diseases have been documented to date.


Cladosporium sp.
(Hormodendrum sp.) – Allergenic. Most commonly identified outdoor fungus. It can cause mycosis. Produces greater than 10 antigens. Antigens in commercial extracts are of variable quality and may degrade within weeks of preparation. Common cause of extrinsic asthma (immediate-type hypersensitivity: type I). Acute symptoms include edema and bronchospasms; chronic cases may develop pulmonary emphysema.


Cunninghamella sp.
– Can cause disseminated and pulmonary infections in immune compromised hosts.


Curvularia sp.
– Allergenic. It may cause corneal infections, mycetoma and infections in immune compromised hosts.

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D
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Drechslera sp. – See Bipolaris sp.

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E
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Epicoccum sp. – Allergenic. Commonly known as a contaminant. No toxic or invasive diseases documented to date.


Exophiala sp.
– Causes the superficial dematiaceous infection, tinea nigra as well as keratomycosis and phaeohyphomycosis. Some species cause infections of the brain and eye as well as cutaneous and subcutaneous tissue.


Exserohilum sp.
– Causes phaeohyphomycosis, most commonly in the nasal sinuses, subcutaneous tissue and cornea. Fatal dissemination infections have been reported but are rare.

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F
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Fonsecaea sp. – Commonly causes chromoblastomycosis (skin lesions). Rarely causes internal infections.


Fusarium sp.
– Allergenic and toxic. A common soil fungus. It is often found in humidifiers. Several species in this genus can produce potent trichothecene toxins. The trichothecene (scirpene) toxin targets the following systems: circulatory, alimentary, skin, and nervous. Produces vomitoxin on grains during unusually damp growing conditions. Symptoms may occur either through ingestion of contaminated grains or possibly inhalation of spores. The genera can produce hemorrhagic syndrome in humans (alimentary toxic aleukia). This is characterized by nausea, vomiting, diarrhea, dermatitis, and extensive internal bleeding. It is also frequently involved in eye, skin and nail infections.

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G
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Geotrichum sp. – The species Geotrichum candidum can cause a secondary infection (geotrichosis) in association with tuberculosis. This rare disease can cause lesions of the skin, bronchi, mouth, lung, and intestine.


Gliocladium sp.
– Allergenic. Commonly considered a contaminant. No toxic diseases caused to date.


Graphium sp.
– May be found as a contaminant. This genus is commonly considered non-pathogenic but may occasionally cause disease in severely immune compromised patients.

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M
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Malbranchea sp. – has been isolated from a case with sinusitis. No other infection associated with Malbranchea has been reported so far.


Microsporum sp.
– Causes ringworm and other skin infections in humans. Usually does not invade living tissue, rather it colonizes the outermost layer. No toxic or invasive diseases documented to date.


Monilia sp.
– Allergenic. Commonly considered a contaminant. This fungus produces soft rot of tree fruits. Other members produce a red bread mold. It is infrequently involved in corneal eye infections.


Mucor sp.
– Allergenic. May cause mucorosis in immune compromised individuals. The sites of infection are the lung, nasal sinus, brain, eye, and skin. Infection may have multiple sites.

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N
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Nigrospora sp. – Allergenic. Commonly considered a contaminant. Involvement in disease has been very rarely reported.


Non-sporulating Fungi
– Allergenic. Commonly considered a contaminant. This genus is commonly considered non-pathogenic. Often associated with allergic symptoms. Other common names include Hyaline mycelia and mycelia sterilia.

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P
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Paecilomyces sp. – Allergenic. The species P. variotii can cause paecilomycosis. Linked to wood-trimmers disease and humidifier associated illnesses. Some members of this genus are reported to cause pneumonia. It may produce arsine gas if growing on arsenic substrate, i.e. wallpapers covered with paris green.


Penicillium sp.
– Allergenic and toxic. A wide number of organisms have placed in this genera. Identification to species is difficult. Often found in aerosol samples. Commonly found in soil, food, cellulose, and grains. It is also found in paint and compost piles. It may cause hypersensitivity pneumonitis and allergic alveolitis in susceptible individuals. Some species can produce mycotoxins. Common cause of extrinsic asthma (immediate-type hypersensitivity: type I). Acute symptoms include edema and bronchospasms; chronic cases may develop pulmonary emphysema.


Phoma sp.
– Allergenic. It may have antigens, which cross-react with those of Alternaria sp. It may cause phaeohyphomycosis, a systematic or subcutaneous disease.


Pithomyces sp.
– Commonly considered a contaminant and, very rarely, has been implicated as an etiological agent in immune compromised hosts. Causes facial eczema in ruminants.


Pseudallescheria boydii
– Causes mycetoma and phaeohyphomycosis, commonly infecting subcutaneous tissue, bones, brain, eyes, lungs, sinuses, meninges, and other body sites. Disseminated infection has been reported in immune compromised patients.

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R
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Rhizomucor sp. – Allergenic. It may cause mucormycosis in immune compromised individuals. It is often linked to occupational allergy. The sites of infection are the lung, nasal sinus, brain, eye, and skin. Infection may have multiple sites.


Rhizopus sp.
– Allergenic. It may cause mucormycosis in immune compromised individuals. It is often linked to occupational allergy. The sites of infection are the lung, nasal sinus, brain, eye, and skin. Infection may have multiple sites.


Rhodotorula sp.
– Allergenic. Positive skin tests have been reported. It has colonized in terminally ill patients.

•
S
•

Scopulariopsis sp. – Allergenic. It may produce arsine gas if growing on arsenic substrate. This can occur on wallpapers covered with paris green. It has been found growing on a wide variety of materials including house dust. It is associated with type III allergy.


Scytalidium sp.
– Known to commonly cause nail and skin infections; there are also rare reports of more deep-seated infections, e.g., subcutaneous abscesses, sinusitis, endophthalmitis, lymphadenitis and fungemia in immune compromised patients.


Sepedonium sp.
– Commonly considered a contaminant. This genus is commonly considered non-pathogenic.


Sporothrix sp.
– Can cause sporotrichosis, however this usually only occurs in populations which are immune compromised.


Sporotrichum sp.
– Allergenic. Commonly considered a contaminant. Has been found in sputa from patients with chronic respiratory disorders, but the significance is unclear.


Stachybotrys sp.
– Toxic. Several strains of this fungus (S. atra, S. chartarum and S. alternans are synonymous) may produce a trichothecene mycotoxin- Satratoxin H - which is poisonous by inhalation. The toxins are present on the fungal spores. This is a slow growing fungus on media. It does not compete well with other rapidly growing fungi. The dark colored fungi grows on building material with a high cellulose content and a low nitrogen content. Areas with relative humidity above 55% and are subject to temperature fluctuations are ideal for toxin production. Individuals with chronic exposure to the toxin produced by this fungus reported cold and flu symptoms, sore throats, diarrhea, headaches, fatigue, dermatitis, intermittent local hair loss, and generalized malaise. The toxins produced by this fungus will suppress the immune system affecting the lymphoid tissue and the bone marrow. Animals injected with the toxin from this fungus exhibited the following symptoms: necrosis and hemorrhage within the brain, thymus, spleen, intestine, lung, heart, lymph node, liver, and kidney. The mycotoxin is also reported to be a liver and kidney carcinogen. Affects by absorption of the toxin in the human lung are known as pneumomycosis. This organism is rarely found in outdoor samples. It is usually difficult to find in indoor air samples unless it is physically disturbed. The spores are in a gelatinous mass. The spores will die readily after release. The dead spores are still allergenic and toxigenic. Percutaneous absorption has caused mild symptoms.


Stemphylium sp.
– Allergenic. Commonly considered a contaminant. No toxic or invasive diseases documented to date.


Syncephalastrum sp.
– Commonly considered a contaminant. Can cause a respiratory infection characterized by a solid fungal ball.

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T
•

Trichoderma sp. – Allergenic and toxic. Commonly considered a contaminant. Occasional reports of infection in immune compromised patients. Several cases of peritonitis have been reported in patients undergoing peritoneal dialysis. It produces antibiotics, which are toxic to humans.


Trichophyton sp.
– Allergenic. Can cause ring worm, athlete's foot, skin, nail, beard, and scalp. Found on soil and skin.


Trichosporon spp
. – A part of the normal flora of mouth, skin and nails, it is the causative agent of superficial and deep infections in humans.

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U
•

Ulocladium sp. – Commonly considered a contaminant. It is widely distributed in nature, especially the soil and decaying plants, and may be isolated from paper, wood, and textiles. May rarely cause human disease, including phaeohyphomycosis and particularly subcutaneous infections.


Ustilago sp.
– Seldom implicated in human disease, but may be inhaled and subsequently isolated from sputum specimens.

•
V
•

Verticillium sp. – Commonly known as a contaminant. Rarely causes inflammation of the cornea.

•
Y
•

Yeast – Various yeasts are commonly identified on air samples. They may cause health problems if a person has had previous exposure and developed hypersensitivity. Yeasts may be allergenic to susceptible individuals when present in sufficient concentrations.


T-2 mycotoxins and Biological warfare-the same destructive agent as Indoor Mold


Tuesday, 05 August 2003

From mold-help.org.
http://www.mold-help.org/content/view/667/


T-2 mycotoxins and Yellow Rain; the same destructive neurological and immunological agents that are found in indoor molds.

MYCOTOXINS (T2)

SUMMARY

Currently, the United States Army is conducting 90% of their biological warfare research in T-2 mycotoxins, according to Dr. William Deagle, in a recent telephone interview. These are the same T-2 mycotoxins that are common properties in many household molds.

OVERVIEW

Mycotoxins are naturally occurring substances produced by fungi as a secondary metabolite that typically affords the organism survival benefit (eg, penicillin). Many of these toxins are pathogenic to animals and humans. An estimated more than 300 mycotoxins are produced by some 350 species of fungi. The T-2 mycotoxin, which is classified as a trichothecene mycotoxin, is elaborated from the fusariam, aspergillus, and stachybotrys species of fungus.

The trichothecene mycotoxins are low molecular weight (250-500 daltons) nonvolatile compounds produced by filamentous fungi (molds) of the genera Fusarium, Myrotecium, Trichoderma, Stachybotrys and others. The structures of approximately 150 trichothecene derivatives have been described in the literature. These substances are relatively insoluble in water but are highly soluble in ethanol, methanol and propylene glycol. The trichothecenes are extremely stable to heat and ultraviolet light inactivation. Heating to 1500o F for 30 minutes is required for inactivation, while brief exposure to NaOCl destroys toxic activity. The potential for use as a BW toxin was demonstrated to the Russian military shortly after World War II when flour contaminated with species of Fusarium was unknowingly baked into bread that was ingested by civilians. Some developed a protracted lethal illness called alimentary toxic aleukia (ATA) characterized by initial symptoms of abdominal pain, diarrhea, vomiting, prostration, and within days fever, chills, myalgias and bone marrow depression with granulocytopenia and secondary sepsis. Survival beyond this point allowed the development of painful pharyngeal/laryngeal ulceration and diffuse bleeding into the skin (petechiae and ecchymoses), melena, bloody diarrhea, hematuria, hematemesis, epistaxis and abnormal bleeding. Pancytopenia, and gastrointestinal ulceration and erosion were secondary to the ability of these toxins to profoundly arrest bone marrow and mucosal protein synthesis and cell cycle progression through DNA replication.

HISTORY AND SIGNIFICANCE

According to the current declassified literature, the T-2 mycotoxin is the only mycotoxin known to have been used as a biological weapon. The trichothecene mycotoxins are low molecular weight compounds (250-500 d, averaging 466 d) that are nonvolatile, relatively insoluble in water, and highly soluble in ethanol, methanol, and propylene glycol. The toxin is highly heat stable and resistant to UV light destabilization (2 important factors when considering an agent as a biological warfare agent).

There is much confusion between inhalation and ingestion of mycotoxins, both being having equally, although slightly different, devastating health effects.

Ingestion: Information regarding the effects of T-2 mycotoxin on humans has been collected from many incidents of accidental ingestion of moldy wheat or corn. One such incident involved the Orenburg district of Russia during World War II. Most men in the village were fighting in the war, leaving the wheat crop unharvested, which resulted in the crop remaining in the fields over the winter. It was harvested in the spring and consumed, causing the clinical syndrome alimentary toxic aleukia (ATA), with varied reports of 10-60% mortality. Some reports demonstrate that T-2 mycotoxin was the operative agent in the "plague" of Athens in 430 BC. Additional information about the clinical effects of T-2 mycotoxin has been demonstrated in the laboratory using human cell cultures and animal models.

Inhalation: Declassified reports prove that T-2 mycotoxin has been used as a simple but effective biological warfare agent on several occasions. The most common strategy was when heavily used in aerosol form ("yellow rain") to produce lethal and non-lethal casualties in in the country of Laos during the Vietnam War. The report of "yellow rain" in remote sections of jungle in Laos (1975-81), which resulted in more than 6,378 deaths, has been viewed as use of T-2 mycotoxin as a biological weapon. Evidence regarding the use of the toxin in Laos has been declassified and well-documented, but many health historians still try to debate this fact to evade the topic of such inhumane abuse of bio-toxins. Other reported uses of T-2 mycotoxin as a biological weapon concern Kampuchea (1979-81) with 1,034 deaths and Afghanistan (1979-81) with 3,042 deaths. The victims were usually unarmed civilians or guerrilla forces. Eyewitness reports sated that the deaths appeared almost instantaneous in some cases, where many appeared to have suffered with severe neurological failure for up to fourteen months. These groups were not protected with masks or chemical protective clothing and had little or no capability of destroying the attacking enemy aircraft. These attacks occurred in remote jungle areas which made confirmation of attacks and recovery of agent extremely difficult.

More recently, it has been prominent that T-2 mycotoxin was disseminated near a US military camp in Saudi Arabia during the Desert Storm campaign. An Iraqi missile detonated over or near the camp. Some of the troops in the area reported immediate symptoms determined to be mycotoxicosis. The government has denied this event, although many witnesses have verified the evidence consistent with the use of this agent. It has also been well-documented that exposure to T-2 mycotoxins and depleted uranium is the exact cause of Gulf War syndrome.

Qualities important to producing an effective chemical or biological weapon are its ease of manufacture, ease of weaponization, durability of the organism or toxin in storage form, ease of dispersal, and chemical stability when exposed to heat although safe levels of ozone and UV radiation have been the only substances that can compromise its effectiveness which humans can also be exposed to. Other factors include ease of concealment and ability to directly obtain the agent or organism that produces the agent. In the early half of the century, biotoxins were investigated as military weapons. These types of weapons fell into disfavor primarily because of problems with weaponization of the biotoxin material. The US closed its biotoxin program in the 1960s. Interest was rekindled in the 1970s with improvements in gene technology and biotechnology. Although the US has no current offensive biological weapons capability, these agents are less expensive than nuclear and chemical weapons and therefore appeal to smaller countries or terrorist organizations. Approximately 90% of all biological warfare studies conducted by the government are in T-2 mycotoxins as a neurological impairment vehicle.

Because of limitations in the manufacture of sufficient quantities, biotoxins are not optimal agents for mass dispersal. This agent is better suited as a small-group assassination tool, since a small amount can be dispersed effectively in enclosed areas. As an assassination tool, T-2 mycotoxins can be used as a food or water-borne poison. The T-2 mycotoxin is the only biologically active toxin effective through dermal exposure and respiratory and gastrointestinal (GI) portals. The route of entry and dose dictate the clinical course. Tissues involved in high cellular turnover (eg, GI and respiratory epithelium, bone marrow cellular elements) are most susceptible to these toxins, but expsoure can be carcinogenic and demyelinating with some species.

CLINICAL FEATURES

T-2 and other mycotoxins may enter the body through the skin and digestive or respiratory epithelium. They are fast acting potent inhibitors of protein and nucleic acid synthesis. Their main effects are on rapidly proliferating tissues such as the bone marrow, skin, mucosal epithelia, and germ cells. In a successful BW attack with trichothecene toxin (T-2), the toxin(s) can adhere to and penetrate the skin, be inhaled, or can be ingested. Clothing would be contaminated and serve as a reservoir for further toxin exposure.

In laboratory rats, the LD50 (dose to cause 50% lethality) is 4 mg/kg when ingested. The LD50 for dermal exposure is reportedly 2-12 mg/kg. In mice, the LD50 for aerosol exposure is 1.2 mg/kg. The trichothecene class of toxins is considered among the most potent naturally occurring toxic substances.

Early symptoms beginning within minutes of exposure include burning skin pain, redness, tenderness, blistering, and progression to skin necrosis with leathery blackening and sloughing of large areas of skin in lethal cases. Nasal contact is manifested by nasal itching and pain, sneezing, epistaxis and rhinorrhea; pulmonary/tracheobronchial toxicity by dyspnea, wheezing, and cough; and mouth and throat exposure by pain and blood tinged saliva and sputum. Acid relfux, nausea, vomiting and watery or bloody diarrhea with abdominal crampy pain occurs with gastrointestinal toxicity. Eye pain, tearing, redness, foreign body sensation and blurred vision may follow entry of toxin into the eyes. Skin symptoms occur in minutes to hours and eye symptoms in minutes. Systemic toxicity is manifested by weakness, prostration, dizziness, ataxia, and loss of coordination. Tachycardia, hypothermia, and hypotension follow in fatal cases. Death may occur in minutes, hours or days. The most common symptoms are vomiting, diarrhea, skin involvement with burning pain, redness and pruritus, rash or blisters, bleeding, and dyspnea.

DIAGNOSIS

Rapid onset of symptoms in minutes to hours supports a diagnosis of a chemical or toxin attack. Mustard agents must be considered but they have an odor, are visible, and can be rapidly detected by a field available chemical test. Symptoms from mustard toxicity are also delayed for several hours after which mustard can cause skin, eye and respiratory symptoms. Staphylococcal enterotoxin B delivered by an aerosol attack can cause fever, cough, dyspnea and wheezing but does not involve the skin and eyes. Nausea, vomiting, and diarrhea may follow swallowing of inhaled toxin. Ricin inhalation can cause severe respiratory distress, cough, nausea and arthralgias. Swallowed agent can cause vomiting, diarrhea, and gastrointestinal bleeding, but it spares the skin, nose and eyes. Specific diagnosis of T-2 mycotoxins in the form of a rapid diagnostic test is not presently available in the field. Removal of blood, tissue from fatal cases, and environmental samples for testing using a gas liquid chromatography-mass spectrometry technique will confirm the toxic exposure. This system can detect as little as 0.1-1.0 ppb of T-2. This degree of sensitivity is capable of measuring T-2 levels in the plasma of toxin victims.

Pathophysiology: The pathophysiology of T-2 mycotoxin is multifactorial. It causes DNA breaks, chromosomal abnormalities, and inhibition of protein synthesis. Inhibition of protein synthesis seems to be the primary cause of symptoms in intoxicated patients. Conflicting reports of the mechanism involving the inhibition of protein synthesis exist. One theory relates it to the toxin's affinity for the 60S ribosomal subunit, therefore inhibiting protein synthesis at the initial step. Another theory involves the inactivation of peptidyl transferase, which inhibits the terminal step of protein synthesis. The mechanism of action on DNA is not clear but is believed to be related indirectly to the cessation of protein synthesis. Chaetomium and stachybotrys produces mycotoxins that have been determined to destroy the myelin sheath, leading to a multiplicity of autoimmune disease including Diabetes II, lupus, and multiple sclerosis.


Signs and symptoms: Exposure causes skin pain, pruritus, easy bruising, redness, vesicles, necrosis and sloughing of epidermis. Effects on the airway include nose and throat pain, nasal discharge, itching and sneezing, cough, dyspnea, wheezing, chest pain, burning, and hemoptysis. Toxin also produces effects after ingestion or eye contact. Severe poisoning results in prostration, infertility, weakness, ataxia, balance/coordination problems, collapse, shock, memory and other cognitive complications including seizures, and death. There are also several U.S. Army studies that quantify permanent immunological and psychological factors that have left permanent disabilities along with IQ abnormalities after exposure.

Diagnosis: Should be suspected if an aerosol attack occurs in the form of "yellow rain" with droplets of yellow fluid contaminating clothes and the environment. Confirmation requires testing of blood, tissue and environmental samples. Serum mycotoxin antibodies tests, DNA, and other blood work can be conducted to determine exposure. Many of these mycotoxins are undetectable in an autopsy.

Treatment: There is no specific antidote other than detoxifying with natural substances and replenishing lipids, nutrients, enzymes, amino acids, and probiotics, and restricted diet. Superactivated charcoal should be given orally if the toxin is swallowed. On extremely rare occasions, radical treatments such as prescriptions like antifungal treatment may be necessary if natural treatment is not effective.

Isolation and Decontamination: Standard Precautions for healthcare workers. Outer clothing should be removed and exposed skin should be decontaminated with soap and water. Eye exposure should be treated with copious saline irrigation. Once decontamination is complete, isolation is not required. Environmental decontamination requires the use of a hypochlorite solution under alkaline conditions such as 1% sodium hypochlorite and 0.1M NAOH with 1 hour contact time. Controlled UV light and ozone can be the only method to decontaminate porous substances with human exposure.

MEDICAL MANAGEMENT

Use of a chemical protective mask and clothing prior to and during a mycotoxin aerosol attack will prevent illness. If a soldier is unprotected during an attack the outer uniform should be removed within 4 hours and decontaminated by exposure to 5% hypochlorite for 6-10 hours. The skin should be thoroughly washed with soap and uncontaminated water if available. The M291 skin decontamination kit should also be used to remove skin adherent T-2. Superactivated charcoal can absorb swallowed T-2 and should be administered to victims of an unprotected aerosol attack. The eyes should be irrigated with normal saline or water to remove toxin.

PROPHYLAXIS

Physical protection of the skin and airway are the only proven effective methods of protection during an attack. Immunological (vaccines) and chemoprotective pretreatments are being studied in animal models, but are not available for field use by the warfighter. The only defense is to wear a protective mask and clothing during an attack. No specific immunotherapy or chemotherapy is available for use in the field.



































































 

 

 

 

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